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Progress in studies of sex determination mechanisms and sex control techniques in

Qian ZHOU,Songlin CHEN

《农业科学与工程前沿（英文）》 2016年第3卷第2期页码 113-123 doi: 10.15302/J-FASE-2016093

摘要： The (half-smooth tongue sole) is a marine flatfish of great commercial value for fisheries and aquaculture in China. It has a female heterogametic sex determination system (ZW/ZZ) and environmental factors can induce sex-reversal of females to phenotypic males, suggesting that it is a promising model for the study of sex determination mechanisms. Additionally, females grow much faster than males and it is feasible to improve the aquaculture production through sex control techniques. This paper reviews the progress in research on sex determination mechanisms research in our laboratory. We have completed whole-genome sequencing and revealed the genome organization and sex chromosome evolution of . A putative male determining gene was identified and DNA methylation was verified as having a crucial role in the sex reversal process. Genetic maps and sex-specific biomarkers have been used in a marker-assisted selection breeding program and for differentiation of the fish sex. Development and improvement of sex control technologies, including artificial gynogenesis and production of breeding fry with high proportion of females, is also reviewed. These research advances have provided insight into the regulation of sex determination and enabled efficient sex management in artificial culturing of .

关键词： Cynoglossus semilaevis sex determination sex control technique

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New decentralized control technique based on substructure and LQG approaches

Ying LEI, Ying LIN,

《机械工程前沿（英文）》 2009年第4卷第4期页码 386-392 doi: 10.1007/s11465-009-0041-x

摘要： Decentralized control is more suitable for structural control of large-scale structures. In this paper, a new decentralized control technique is proposed based on the linear quadratic Gaussian (LQG) and substructure approaches. A large-scale structure is divided into a set of smaller substructures. Each substructure is controlled by its own local controller with interaction forces at substructural interfaces, which are considered as “unknown external inputs” to the substructure concerned. An algorithm of recursive least squares estimation for the unknown excitation is proposed. A numerical example of the decentralized control of a tall building is studied to illustrate the new proposed algorithm. Simulation results show that the proposed decentralized control provides satisfactory control performance when comparing with the conventional centralized LQG control algorithm and is viable for the future structural control of large-scale structures.

关键词： substructures decentralized control linear quadratic Gaussian (LQG) Kalman filter unknown input least-squares estimation

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Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of sex

Dongping Ning, Zhan Zhang, Kun Qiu, Lin Lu, Qin Zhang, Yan Zhu, Renzhi Wang

《医学前沿（英文）》 2020年第14卷第4期页码 498-505 doi: 10.1007/s11684-020-0791-8

摘要： Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies. Distinguishing the various causes of DSD is quite difficult in clinical practice, even for senior general physicians because of the similar and atypical clinical manifestations of these conditions. In addition, DSD are difficult to diagnose because most primary doctors receive insufficient training for DSD. Delayed diagnoses and misdiagnoses are common for patients with DSD and lead to poor treatment and prognoses. On the basis of the principles and algorithms of dynamic uncertain causality graph (DUCG), a diagnosis model for DSD was jointly constructed by experts on DSD and engineers of artificial intelligence. “Chaining” inference algorithm and weighted logic operation mechanism were applied to guarantee the accuracy and efficiency of diagnostic reasoning under incomplete situations and uncertain information. Verification was performed using 153 selected clinical cases involving nine common DSD-related diseases and three causes other than DSD as the differential diagnosis. The model had an accuracy of 94.1%, which was significantly higher than that of interns and third-year residents. In conclusion, the DUCG model has broad application prospects as a computer-aided diagnostic tool for DSD-related diseases.

关键词： disorders of sex development (DSD) intelligent diagnosis dynamic uncertain causality graph

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Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken

Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI

《农业科学与工程前沿（英文）》 2014年第1卷第3期页码 242-249 doi: 10.15302/J-FASE-2014018

摘要： A unique characteristic of the Silkie chicken is its fibromelanosis phenotype. The dermal layer of its skin, its connective tissue and shank dermis are hyperpigmented. This dermal hyperpigmentation phenotype is controlled by the sex-linked inhibitor of dermal melanin gene ( ) and the dominant fibromelanosis allele. This study attempted to confirm the genomic region associated with . By genotyping, was found to be closely linked to the region between GGA_rs16127903 and GGA_rs14685542 (8406919 bp) on chromosome Z, which contains ten functional genes. The expression of these genes was characterized in the embryo and 4 days after hatching and it was concluded that , encoding methylthioadenosinephosphorylase, would be the most likely candidate gene. Finally, target DNA capture and sequence analysis was performed, but no specific SNP(s) was found in the targeted region of the Silkie genome. Further work is necessary to identify the causal mutation located on chromosome Z.

关键词： sex-linked inhibitor of dermal melanin (Id) Silkie chromosome Z

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Isolation and characterization of a bacterial strain that efficiently degrades sex steroid hormones

JI Shulan, LIU Zhipeng, REN Haiyan, LIU Zhipei

《环境科学与工程前沿（英文）》 2007年第1卷第3期页码 325-328 doi: 10.1007/s11783-007-0055-8

摘要： A bacterial strain, ZY3, growing on sex steroid hormones as the sole source of carbon and energy was isolated from the sewage treatment plant of a prophylactic steroids factory. ZY3 degrades the 3-methoxy-17-hydroxy-1,3,5(10),8(9)--4-estren (MHE). This strain was preliminarily identified as sp. ZY3 according to its morphology and its 16S rRNA gene sequence. During the experimental period (72 h), the optimum temperature, pH and 3-MHE concentration for the degradation of hydride by the strain ZY3 were 35vH, 10 and 10 mg/L, respectively. The degradation rate of the sex steroid hormones increased to 87% and 85% after the addition of maltose and peptone, respectively.

关键词： maltose optimum temperature prophylactic 3-methoxy-17-hydroxy-1 3 5 addition

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高速主轴动平衡及其在线控制技术

章云,梅雪松

《中国工程科学》 2013年第15卷第1期页码 87-92

摘要：

针对机床主轴在线自动平衡控制问题，阐述了高速主轴不平衡识别方法和在线自动平衡技术国内外现状，分析了喷液式在线自动平衡装置原理，设计了喷液式平衡系统，并通过高速主轴实验对该系统的有效性进行了验证。研究结果表明，主轴经过平衡后，不平衡量振动值由1.60 mm/s降至0.34 mm/s，主轴失衡振动得到了有效抑制。

关键词：高速主轴在线动平衡振动控制

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盾构隧道长距离独头掘进的控制测量技术

许维青,韩福忠

《中国工程科学》 2010年第12卷第12期页码 56-58

摘要：

北京地下直径线盾构独头掘进距离达5.2 km，因此隧道贯通精度控制难度大。通过测量精度分析，单纯通过导线测量已不能满足设计规定的贯通限差要求，施工中通过导线直接传递定向、洞内加测陀螺边、地上地下控制网紧密联系等辅助方法，提高了贯通横向误差的精度，达到了预期效果。

关键词：盾构长距离独头掘进控制测量

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Analysis of load transfer stability control strategy in hydraulic synchronized continuous slippage

LIU Yan-bo, WU Jian-zhong, ZHANG Xuan

《机械工程前沿（英文）》 2006年第1卷第2期页码 222-226 doi: 10.1007/s11465-006-0007-1

摘要： Hydraulic synchronized continuous slippage technique, which integrates mechanical, electrical and hydraulic control, is introduced in this paper for the practical requirements of some construction projects. The core of this technique (the stability of the load transfer) is illustrated in detail. Three speed control strategies to transfer the load excessive, lower and same speed are presented to accomplish the smoothness and stability in the process of slippage. An optimization of the speed control strategy (same speed) is deduced from the modeling analysis and its validity and maneuverability are tested by practical application, which provides evidence for similar engineering in theory and practice.

关键词： excessive slippage technique optimization continuous slippage engineering

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湖泊底泥污染控制技术及其适用性探讨

胡小贞,金相灿,卢少勇,储昭升

《中国工程科学》 2009年第11卷第9期页码 28-33

摘要：

对目前国内外应用较多的三类底泥污染控制技术，即环保疏浚技术、原位覆盖技术、原位钝化技术的技术特点、关键技术内容、可能产生的主要环境问题及其应用现状进行了详细分析。在各项技术的优缺点、费用效益比较的基础上，提出环保疏浚技术适用于大面积重污染湖区或河口底泥污染的控制，原位覆盖技术适用于中深水湖泊、海域或河流底泥污染的控制，原位钝化技术适合于风浪扰动不大、非饮用水源地功能湖泊底泥污染的控制。并对三项技术在我国湖泊底泥污染控制领域的应用前景进行了展望。

关键词：湖泊底泥污染控制技术适用性

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鄂东大桥混合梁斜拉桥合龙技术

刘明虎,谭皓,徐国平,赵灿晖

《中国工程科学》 2011年第13卷第10期页码 99-104

摘要：

结合世界第二混合梁斜拉桥——主跨926 m的鄂东大桥，研究了大跨径混合梁斜拉桥中跨合龙方案的影响因素及关键技术，确定采用加载合龙方案。加载合龙方法具有较好的温度适应性，对成桥结构线形和受力影响很小，满足无应力施工控制方法的要求，适用于大跨径混合梁斜拉桥。研究成果及实践经验对同类型桥梁具有借鉴指导意义。

关键词：鄂东大桥混合梁斜拉桥合龙技术加载合龙无应力状态控制法

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General modeling and optimization technique for real-world earth observation satellite scheduling

《工程管理前沿（英文）》页码 695-709 doi: 10.1007/s42524-023-0263-3

摘要： Over the last two decades, many modeling and optimization techniques have been developed for earth observation satellite (EOS) scheduling problems, but few of them show good generality to be engineered in real-world applications. This study proposes a general modeling and optimization technique for common and real-world EOS scheduling cases; it includes a decoupled framework, a general modeling method, and an easy-to-use algorithm library. In this technique, a framework that decouples the modeling, constraints, and optimization of EOS scheduling problems is built. With this framework, the EOS scheduling problems are appropriately modeled in a general manner, where the executable opportunity, another format of the well-known visible time window per EOS operation, is viewed as a selectable resource to be optimized. On this basis, 10 types of optimization algorithms, such as Tabu search and genetic algorithm, and a parallel competitive memetic algorithm, are developed. For simplified EOS scheduling problems, the proposed technique shows better performance in applicability and effectiveness than the state-of-the-art algorithms. In addition, a complicatedly constrained real-world benchmark exampled by a four-EOS Chinese commercial constellation is provided, and the technique is qualified and outperforms the in-use scheduling system by more than 50%.

关键词： earth observation satellite scheduling general technique optimization algorithm commercial constellation real-world benchmark

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西南铁路地质灾害与勘察防治技术成就

朱颖,蒋良文,屈科,李光辉,曹化平

《中国工程科学》 2008年第10卷第4期页码 29-37

摘要：

我国西南地区处于青藏高原周边地带，位于印度板块与欧亚板块碰撞带东侧附近，地质构造十分复杂，地质灾害严重。结合宝成、贵昆、成昆、襄渝、南昆、内昆、渝怀等西南复杂地质艰险山区重要干线铁路的勘察设计、施工和运营，总结概括了西南铁路地质灾害的基本情况，并较系统地介绍了几种主要地质灾害的铁路地质勘察和工程防治技术经验。

关键词：西南地区铁路地质灾害勘察防治技术

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Control efficiency optimization and Sobol’s sensitivity indices of MTMDs design parameters for buffeting

Nazim Abdul NARIMAN

《结构与土木工程前沿（英文）》 2017年第11卷第1期页码 66-89 doi: 10.1007/s11709-016-0356-8

摘要： This paper studies optimization of three design parameters (mass ratio, frequency ratio and damping ratio) of multiple tuned mass dampers MTMDs that are applied in a cable stayed bridge excited by a strong wind using minimax optimization technique. ABAQUS finite element program is utilized to run numerical simulations with the support of MATLAB codes and Fast Fourier Transform FFT technique. The optimum values of these three parameters are validated with two benchmarks from the literature, first with Wang and coauthors and then with Lin and coauthors. The validation procedure detected a good agreement between the results. Box-Behnken experimental method is dedicated to formulate the surrogate models to represent the control efficiency of the vertical and torsional vibrations. Sobol’s sensitivity indices are calculated for the design parameters in addition to their interaction orders. The optimization results revealed better performance of the MTMDs in controlling the vertical and the torsional vibrations for higher mode shapes. Furthermore, the calculated rational effects of each design parameter facilitate to increase the control efficiency of the MTMDs in conjunction with the support of the surrogate models.

关键词： MTMDs power spectral density fast Fourier transform minimax optimization technique Sobol’s sensitivity indices Box-Behnken method

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构建我国农业信息化技术支持体系的探讨

郭书普,张立平,沈基长,董伟

《中国工程科学》 2005年第7卷第9期页码 89-94

摘要：

阐述了农业信息化的基本特征，介绍了农业信息化技术支持体系的发展现状，分析了存在的问题，指出现阶段加快农业信息技术体系建设应当重点抓好农业信息贮藏技术的研究、农业信息应用技术的开发、农业信息传播网络的建设。

关键词：农业信息化技术支持体系信息贮藏技术信息应用技术信息传播网络

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The electrostatic-alloy bonding technique used in MEMS

WANG Wei, CHEN Wei-ping

《机械工程前沿（英文）》 2006年第1卷第2期页码 238-241 doi: 10.1007/s11465-006-0011-5

摘要： Electrostatic-alloy bonding of silicon wafer with glass deposited by Au to form Si/Au-glass water, and bonding of Si/Au-glass with silicon wafer were researched during fabrication of pressure sensors. The silicon wafer and glass wafer with an Au film resistor were bonded by electrostatic bonding, and then Si-Au alloy bonding was formed by annealing at 400vH for 2 h. The air sealability of the cavity after bonding was finally tested using the N filling method. The results indicate that large bond strength was obtained at the bonding interface. This process was used in fabricating a pressure sensor with a sandwich structure. The results indicate that the sensor presented better performances and that the bonding techniques can be used in MEMS packaging.

关键词： Si/Au-glass strength MEMS packaging process sandwich structure